Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion
Recruiting
N/A
Interventional Study
Diabete Type 2
Abdominal Obesity
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 80
- Sex
- Male
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 45 (estimated)
- Sponsor
- Centre Hospitalier Universitaire Dijon · Other
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About This Trial
Abdominal obesity and type 2 diabetes are associated with the hyperactivation of the endocannabinoid system. Several animal and human studies indicate that circulating endocannabinoid (EC) levels are correlated with body fat. Thus, adipose tissue, which possesses the enzymatic machinery for the synthesis of ECs, could be the main producer of plasma ECs.
Today, it is clearly established that stimu…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Controls:
* men or post-menopausal women aged between 18 and 80
* gave oral consent
* to undergo visceral surgery
Non-diabetic obese subjects:
* men or post-menopausal women aged between 18 and 80
* BMI \> 30
* gave oral consent
* to undergo visceral surgery
Obese diabetic …
Contacts