Assessment of Retreatment With Lutathera® in Patients With New Progression of Intestinal Well-differenciated NET

Inclusion Criteria: * Age ≥ 18 years, * Histologically proven intestinal G1 or G2 neuroendocrine tumors (NET), * Patient previously treated with 4 cycles of Lutathera® (defined as "First PRRT"), * Disease control after "First PRRT" ≥ 12 months, * Patient presenting a progression of disease (clinic, biologic and/or radiologic) after a first PRRT, * Decision of retreatment with Lutathera® (defined as "Second PRRT") validated by RENATEN and/or multidisciplinary tumor board and in the scope of the French reimbursement process, * ECOG performance status 0-2, * Life expectancy ≥ 6 months as prognosticated by the physician, * Somatostatin receptor imaging positive imaging (SSTRi+) disease within 4 months prior to inclusion : (may be PET imaging (68Ga-based SSTR analogues) or scintigraphy imaging: 111In-pentetreotide or 99mTc-octreotide. At least 90% of lesions must be positive for SSTRi with a significant uptake (\>= liver of surrounding tissue), * Measurable disease per RECIST 1.1 (Appendix 1), on CT/MRI scans, defined as at least 1 lesion with ≥ 1 cm in longest diameter, and ≥ 2 radiological tumors lesions in total, * Adequate bone marrow reserve (Hb \> 8 g/dl, neutrophils ≥ 1500/mm³ and platelets ≥ 80 000/mm³), * Negative pregnancy test in women of childbearing potential (the β-HCG dosage must be ≤ 4 days before inclusion). Women who have no reproductive potential are postmenopausal women or women who have had permanent sterilization, eg. tubal occlusion, hysterectomy, bilateral salpingectomy), * Effective contraception in men or women of childbearing or pre-menopausal age and up to a minimum of 6 months following the end of treatment, * Patient´s signed written informed consent, * Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests and other study procedures, * Affiliation to the French Social Security System Exclusion Criteria: * Patient who did not respond (no CR, PR or SD) to "first PRRT". * Radiological progression after two cycles of "Second PRRT" according to RECIST version 1.1, * Grade 4 hematotoxicity and/or nephrotoxicity during the initial PRRT, or unresolved AEs categorized as Grade 2 or higher (as per Common Terminology Criteria for Adverse Events (CTCAE v5.0) from previous PRRT cycles or any other therapy for NET, excluding alopecia and peripheral neuropathy, * Pancreatic NET, * NeuroEndocrine Carcinoma, * Prior external beam radiation therapy to more than 25% of the bone marrow, * Severe renal (estimated Glomerular Filtration Rate (GFR) according to Modification of Diet in Renal Disease (MDRD) \< 40 mL/min or nephrotic syndrome) or hepatic insufficiency (Alanine aminotransferase (ALT)/ aspartate aminotransferase (AST) \> 2.5 x ULN or ALT/AST \> 5 x ULN if liver function abnormalities are due to the underlying malignancy and/or total serum bilirubin \> 2.5 x ULN), * Serum albumin \< 3.0 g/dL unless prothrombin time is within the normal range, * Uncontrolled diabetes mellitus as defined by a fasting blood glucose above 2 ULN, * Uncontrolled decompensated heart failure, myocardial infarction uncontrolled, stroke, pulmonary embolism or revascularization procedure, unstable angina pectoris, uncontrolled cardiac arrhythmia, and clinically significant bradycardia during the last 12 months, * Hypertension that cannot be controlled despite medications (≥ 160/95 mmHg despite optimal medical therapy) * Brain metastases (unless these metastases have been treated and stabilized for at least 24 weeks, prior to enrolment in the study. Patients with a history of brain metastases must have a head CT scan with contrast or MRI to document stable disease prior to enrolment in the study), * Pregnancy or breast feeding, * Substance abuse, medical, psychological, or social conditions that may interfere with the patient's participation in the study or evaluation of the study results, * Known hypersensitivity to any of the study drugs, study drug classes, or any constituent of the products, * Concomitant participation or participation within the last 30 days in another clinical trial, * History of other solid tumor in 5 years before the inclusion excepted of cancer in situ of the cervix and skin cancer (basal or squamous cell) treated and controlled. * Legal incapacity or physical, psychological or mental status interfering with the patient's ability to sign the informed consent or to terminate the study.