Cefixime for Treating Syphilis
Cefixime Clinical Trial
Recruiting
Phase 3
Interventional Study
Syphilis
Human Immunodeficiency Virus
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 400 (estimated)
- Sponsor
- University of Southern California · Other
Who this trial is looking for
This trial is looking for adults with syphilis to compare cefixime to another treatment. Participants need to meet certain health requirements and must be able to attend follow-up visits.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years of age or older.
- I have been diagnosed with primary, secondary, or early latent syphilis.
- I have an RPR titer of 1:8 or higher within the last 3 weeks.
- I can provide informed consent.
- I have HIV but am on treatment and have a viral load under 200 copies/mL or a CD4 count of 350 cells/mm3 or higher.
You may not be able to join if
- I am pregnant or have a positive pregnancy test.
- I have signs and symptoms of neurosyphilis.
- I have a serofast RPR titer.
- I have taken antibiotics for syphilis in the past 7 days.
- I have interrupted my HIV treatment for more than 4 weeks recently.
- I am allergic to cephalosporins or penicillin.
- I cannot attend follow-up visits.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
This study aims to evaluate the efficacy of cefixime compared to benzathine penicillin G in the treatment of syphilis.
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Diagnosed cases of primary, secondary, or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment
* 18 years of age or older
* Able to provide informed consent
* Individuals with HIV infection must be on treatment for HIV infection and virologically suppre…
Contacts