A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients
Recruiting
N/A
Interventional Study
Persistent Depressive Disorder
Treatment-resistant Depression
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 396 (estimated)
- Sponsor
- University of Greifswald · Other
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About This Trial
The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Primary DSM-5 diagnosis of PDD (300.4, 296.2x, 296.3x)
* Total Hamilton Depression Rating Scale (HDRS-24) Score ≥ 20
* Treatment-resistance (TR) (defined by the ATHF-SF or medication intolerance or one psychotherapy at least 25 sessions by a certified therapist in the current …
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