Guselkumab for Psoriasis to Prevent Joint Issues
Multi-Center PAMPA Study
Recruiting
Phase 4
Interventional Study
Psoriasis
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 176 (estimated)
- Sponsor
- NYU Langone Health · Other
Who this trial is looking for
This trial is looking for people with psoriasis at risk of developing arthritis. Participants will receive either the study drug, guselkumab, or a placebo, while doctors monitor their condition over time.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years old or older
- I have been diagnosed with psoriasis for at least 2 years
- I can provide informed consent
- I have psoriasis affecting more than 3% of my body
- I have imaging findings indicating certain ultrasound abnormalities
You may not be able to join if
- I have joint pain or swelling currently
- I am using immunosuppressive medication now or have used biologic therapy in the past
- I have tested positive for rheumatoid arthritis markers
- I have an active cancer right now
- I have a history of certain joint conditions that could affect my results
- I have an active infection or untreated tuberculosis
- I am allergic to guselkumab
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
This is a multi-center (North-America), randomized, double-blind, placebo-controlled, wait-list, interventional, preventive trial of guselkumab in high-risk psoriasis patients compared to non-biologic standard of care.
The primary objective of the proposed trial will be to test the hypothesis that a prolonged, unresolved skin inflammation coupled with musculoskeletal power-doppler ultrasound (MSK…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. 18 years old or older;
2. Both male \& female;
3. Psoriasis diagnosis (per dermatologist) for at least 2 years (in at least 30% of participants);
4. Willing and able to provide informed consent;
5. Fulfillment of HR-PsO criteria (Psoriasis (PsO) patients will meet the definit…
Contacts