No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
55 and older
Sex
Any
Study type
Observational
Participants needed
10,000 (estimated)
Sponsor
Columbia University · Other
Who this trial is looking for
This trial is looking for families or individuals with a history of Alzheimer's Disease. Participants will provide information about their family health history to help researchers understand the genetic factors of the disease.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Alzheimer's Disease or a related disorder.
I have at least one living sibling with Alzheimer's Disease.
I have another living family member affected by Alzheimer's Disease or someone who is unaffected and at least 60 years old.
I can consent to participate or have someone who can consent for me.
You may not be able to join if
I cannot find a suitable informant for the study.
I am unsure about my Alzheimer's Disease diagnosis.
I have another diagnosis that explains my symptoms.
I do not want to participate.
I do not have a living sibling with Alzheimer's Disease or related disorder.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
* a living sibling with probable or possible AD;
* a t…
Inclusion Criteria:
* Established diagnosis of definite or probable AD or have a diagnosis of a related neurodegenerative disorder such as Frontotemporal Dementia (FTD) or Lewy Body Dementia (LBD) (will also recruit sporadic FTD and LBD) cases.
* a living sibling with probable or possible AD;
* a third living relative affected with AD (onset age 50 or older) or unaffected (60 or older);
* participants in the proband's generation with an identified companion serving as an informant;
* participants who have capacity to consent or participants lacking capacity to consent with a surrogate/proxy in place to provide consent.
Exclusion Criteria:
* failure to identify an appropriate informant;
* uncertainty of the clinical diagnosis of Alzheimer's disease or other related disorder;
* discovery of additional diagnosis that could account for the clinical manifestations;
* unwillingness to participate;
* failure to identify a living sibling with AD or other related disorder (except in the cases of sporadic FTD and sporadic LBD);
* participants lacking the capacity to consent who do not have a surrogate or proxy or next of kin to provide consent.
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