Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation
Recruiting
Phase 3
Interventional Study
Critical Illness
Respiratory Failure
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 90
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 420 (estimated)
- Sponsor
- University of Turin, Italy · Other
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About This Trial
Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed. The primary aim of the PREVENTION trial is to compare the effect of the pre-emptive use of noradrenaline versus no peri-intubation use of noradrenaline on incidence of cardiovascular collapse following TI in adult critically il…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patient is admitted or scheduled for admission to a participating study hospital
* Planned procedure is tracheal intubation and planned operator is a provider expected to routinely perform endotracheal intubation in the participating unit
* Critical illness (i.e. life-threaten…
Contacts