No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
8 – 25
Sex
Any
Study type
Observational
Participants needed
90 (estimated)
Sponsor
Masonic Cancer Center, University of Minnesota · Other
Who this trial is looking for
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This study aims to more accurately assess cardiac function, ventilation and exercise capacity in a non-invasive fashion, and to better characterize exercise intolerance in the setting of three populations of individuals with chronic diseases of childhood (acute lymphoblastic leukemia (ALL), chronic lung disease (CLD) of prematurity, and post-heart transplant (HT))
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Cases:
* Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
* 8-25 years old
* Height: ≥ 48 inches
* Ambulatory without assistance
* English speaking
* Normotensive (\<95th percentile for age;…
Inclusion Criteria:
* Cases:
* Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant
* 8-25 years old
* Height: ≥ 48 inches
* Ambulatory without assistance
* English speaking
* Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
* SpO2 \>92%
* Not pregnant
* ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry
* Controls
* 8-25 years old
* Height: ≥ 48 inches
* Ambulatory without assistance
* English speaking
* No history of arrhythmia or known cardiac dysfunction at baseline
* Normotensive (\<95th percentile for age; okay if managed with antihypertensive medication)
* SpO2 \>95%
* Not pregnant
Exclusion Criteria:
* Cases:
* ALL specific: received cranial radiation, bone marrow transplant recipients
* Investigator or patient's primary physician deems the patient unsuitable for the study
* Controls:
* History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function
* Investigator deems the patient unsuitable for the study
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