Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis
Recruiting
Observational Study
Cerebrovascular StrokeCerebral Artery Stenosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 80
Sex
Any
Study type
Observational
Participants needed
850 (estimated)
Sponsor
Yi Yang · Other
Who this trial is looking for
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In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ranging from 18 to 80, both genders
* Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%)
* Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery sup…
Inclusion Criteria:
* Age ranging from 18 to 80, both genders
* Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%)
* Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery supplying area
* Onset of disease \<30 d before enrollment
* Modified Ranking Scale (mRS) ≤1 before stroke onset
* National Institutes of Health Stroke Scale (NIHSS) ≤20
* Sufficient bilateral temporal bone windows for insonation of the middle cerebral artery
* Be conscious, and able to cooperate with CA assessment
* Willing to participate and sign the informed consent
Exclusion Criteria:
* Vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), or posterior cerebral artery (PCA) stenosis; Bilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis(rate of stenosis ranging from 50-99%)
* Patients who have received or plan to undergo intravascular interventional treatment/endarterectomy
* Other intracranial diseases, including cerebral hemorrhage (primary or secondary), intracranial neoplasm, aneurysm, arteriovenous malformation, etc.
* Evidence for embolic stroke, such as atrial fibrillation, prosthetic valve surgery, and suspected endocarditis, etc.
* Arrhythmia, anemia and hyperthyroidism which may influence the stability of cerebral blood flow diagnosed by two physicians by electrocardiogram and laboratory tests.
* Dementia, severe anxiety, depression, and other mental diseases
* Malignant neoplasm and expected lifetime \<2 years
* Enrolled in other clinical trails within 6 months
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