Biomarker Research in Inherited Movement Disorders

Inclusion Criteria: Common inclusion criteria for all participants: \- - Affiliated with a social security system or beneficiary of such a regime Group of patients: Any patient with inherited hyperkinetic movement disorders can be included in the study according to the following criteria: Woman or man; * Clinical diagnosis of inherited hyperkinetic movement disorders with or without a genetic diagnosis * With or without familial history of the disease * Age ≥ 7 years; * Signed Informed consent by the patient or both of holders of the parental authority for minors, or by the le;gal guardian for adults under guardianship Group of at-risk individuals: * Woman or man; * Age ≥ 18 years old; * A first-degree relative of a patient with inherited hyperkinetic movement disorders * OR a carrier of an identified pathogenic variant or expansion in one of the pathological gene variant involved in one of these diseases; * Normal neurological examination; according to disease specific scales * Signed Informed consent by the subject or by the legal guardian for adults under guardianship Group of healthy controls: * Woman or man; * Aged ≥ 18 years old; * Free of known neurological pathology; * No significant neurological symptoms; * Signed Informed consent by the subject Common inclusion criteria for elective participant for skin biopsy (optional): - Age ≥10 ans * Ability to undergo a skin biopsy Common inclusion criteria for elective participant for MRI examination (optional): - Ability to undergo a MRI. Exclusion Criteria: Absolute criteria for non-inclusion for all groups: \- Person deprived of their liberty by judicial decision Contra-indications to MRI examination\* (optional): metallic implant, pacemaker, artificial heart valve, brain vascular malformation, aneurysm clips, exposed by metallic fragments, artificial implants, peripheral or neuronal stimulator, insulin pump, intravenous catheter, epilepsy, metallic contraceptive device, claustrophobia, Contra-indication to skin biopsy (optional): * Taking anticoagulant or antiplatelet medication (see above), * History of hemostasis disorders, * Presence of hemorrhagic risk verified by a coagulation test