Amyloid-β Clearance Mechanisms in Alzheimer's Disease

Inclusion Criteria: * Diagnosis of amnestic MCI or AD dementia or clinical normal * Able to provide written informed consent * Unchanged pharmacotherapy within 4 days prior to the study specific assessments * Fluent in German Exclusion Criteria: * Unable to give informed consent or has a legal guardian * Other severe mental disorder, e.g. schizophrenia or bipolar affective disorder * Clinically relevant depression * Acute suicidality * Current alcohol, drug or medication abuse * History of severe traumatic brain injury within 3 months prior to inclusion * Structural lesions of the basal ganglia or brain stem * Severe neurological disorder including (but not limited to) epilepsy, systemic disorders, stroke, repeated transient ischaemic attacks, increased brain intracranial pressure, normal pressure hydrocephalus * Severe medical disorders including (but not limited to) heart failure, respiratory failure, uncontrolled severe arterial hypertension * Electronic implants (e.g. cardiac pacemaker) or other MRI contraindication * Renal failure \> stage 3 (GFR \< 30 mL/min) * Pregnancy * Unresolved malignancies within two years prior to inclusion * Severe current infections or other chronic or systemic disorders * Other circumstances which preclude participation based on the investigator's judgement