Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
Recruiting
Phase 4
Interventional Study
Endometriosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 45
- Sex
- Female
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 28 (estimated)
- Sponsor
- Penn State University · Other
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About This Trial
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Women between the ages of 18 and 45 years with endometriosis (diagnosis by prior laparoscopy by subject's own physician \<10 years prior, and reported by the subject to the researchers)
* Tylenol if the subject has acute pain is allowed
* IUD contraceptive use (copper or levon…
Contacts