Adaptive Neurostimulation for Parkinson's Disease Sleep Issues

Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)

Recruiting N/A Interventional Study
Parkinson's Disease Sleep Fragmentation
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
20 (estimated)
Sponsor
University of Nebraska · Other
Who this trial is looking for

This trial is looking for adults with Parkinson's Disease who have problems with sleep. Participants will receive a treatment to improve their sleep quality while also addressing motor symptoms associated with their condition.

Are You a Good Fit for This Trial?
Rules you out Restless Leg SyndromeObstructive Sleep Apnea

You may be able to join if

  • I have been diagnosed with Parkinson's disease for at least 4 years.
  • I have severe motor symptoms despite taking Parkinson's medications.
  • I have a UPDRS-III score between 20 and 80 when off medication.
  • I have not responded well to oral Parkinson's medications.
  • I am approved for deep brain stimulation surgery.
  • I am between 18 and 80 years old.
  • I can participate in follow-up care for up to 9 years.

You may not be able to join if

  • I have a medical condition that raises surgical risks.
  • I am currently pregnant.
  • I have significant untreated depression.
  • I have personality or mood disorders that may disrupt the study.
  • I am undergoing treatment with electroconvulsive therapy or similar.
  • I have a previously implanted stimulation system.
  • I have a history of drug or alcohol abuse.
  • I have conditions affecting my cognitive ability.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial
Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US. The prevalence of sleep dysfunction in PD is estimated at nearly 80-90% which includes sleep fragmentation, insomnia, rapid eye movement (REM or dream sleep) Sleep Behavior Disorder (RBD), Restless legs syndrome (RLS), periodic lim…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Signed informed consent * Diagnosis of Idiopathic Parkinson's disease (PD) with motor symptoms present for a minimum of 4 years * Severe motor symptoms (e.g., motor fluctuations, dyskinesia, tremor, bradykinesia, rigidity) despite optimized medical therapy, that warrant surgic…
Contacts

Dulce Maroni, PhD

402-836-9751

dmaroni@unmc.edu

CONTACT