Pharmacogenetics of Response to GLP1R Agonists
Recruiting
Phase 1
Interventional Study
Obesity
Diabetes Type 2
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 89
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 600 (estimated)
- Sponsor
- University of Maryland, Baltimore · Other
Who this trial is looking for
This trial is looking for healthy adults of Amish descent who are overweight or obese and have a body mass index of 27 or higher. They cannot have diabetes, certain medical conditions, or a personal or family history of specific thyroid cancers. Additionally, women who are sexually active and could become pregnant are not eligible to participate.
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About This Trial
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA. Pharmacodynamic responses to GLP1R agonist will be assessed by conducting frequently sampled intravenous glucose tolerance tests (FSIGT) both before and after semaglutide for six weeks. The proposal proposes two specific aims:
1. Specific Aim #1. To id…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* BMI greater than or equal to 27 kg/m2
* Of Amish Descent
Exclusion Criteria:
* Woman of childbearing age who is sexually active
* History of diabetes (HbA1c \> 6.5% or random glucose \>200 mg/dL)
* Known allergy to semaglutide
* Medical issues, which in the judgment of the r…
Contacts