Natural History Study of CADASIL
Recruiting
Observational Study
Cardiovascular Disease
Arterial Stiffness
Germline Mutation in the NOTCH 3 Gene
Pathogenesis of CADASIL
Clinical Phenotype of CADASIL
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 100
- Sex
- Any
- Study type
- Observational
- Participants needed
- 155 (estimated)
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI) · NIH
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About This Trial
Background:
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy) is a genetic disorder. It causes narrowing of the small blood vessels and can lead to strokes and dementia. Researchers want to monitor people with CADASIL over time.
Objective:
To learn more about how CADASIL affects a person s blood vessels over time.
Eligibility:
Adults ages 18 a…
Trial Locations
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Eligibility Criteria
* INCLUSION CRITERIA:
Eligibility for this study may be determined based on information collected under other NHLBI-approved protocols, outside records and patient report.
In order to be eligible to participate in this study, an individual must meet criteria 1 \& 2 and either criteria 3 or 4:
1. …
Contacts