Combined Kidney and Hematopoietic Stem Cell Transplantation for Tolerance Induction
Recruiting
Phase 2
Interventional Study
Renal Transplantation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 20 (estimated)
- Sponsor
- Rabin Medical Center · Other
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About This Trial
Combined transplantation of kidney and bone marrow between HLA-matched sibling donor-recipient pairs to induce immune tolerance in order to enable complete discontinuation of immunosuppressive therapy without kidney rejection. Hematopoietic stem cells are collected from the donor 4 to 8 weeks before kidney transplantation, CD34 cells are enriched by positive selection and cryopreserved. The day af…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age older than 18 years
* Matched siblings
* No contra-indication to thymoglobuline or total lymphoid irradiation
Exclusion Criteria:
* Pregnant women or breast feeding
* Infection with HIV, HBV or HCV
* Previous or presnt malignancy
Contacts