Morning Versus Bedtime Dosing of Antihypertensive Medication

Inclusion Criteria: 1. Male or female patients aged 18-70 years old; 2. Never treated for hypertension or stopped using antihypertensive drugs for at least 2 weeks; 3. In the two screenings,the clinical systolic BP should be in the range of 140-159 mmHg, the diastolic BP \< 100 mmHg; 4. The average 24-hour systolic BP ≥130mmHg, daytime systolic BP ≥ 135 mmHg, and nighttime systolic BP ≥ 120 mmHg; 5. The average of bilateral brachial-ankle pulse wave velocity ≥14m/s; 6. Be willing to participate in the trial, sign the informed consent form, and be able to visit doctors by himself or herself. Exclusion Criteria: 1. Secondary hypertension; 2. Concomitant obstructive sleep apnea (STOP-BANG score ≥ 5), insomnia, Parkinson's syndrome, or nocturnal polyuria and other diseases that affect nighttime BP; 3. Need to work at night; 4. Ambulatory BP monitoring was invalid (\<70% valid readings, or \<20 daytime readings or \<7 nighttime readings); 5. Concomitant diseases that need taking medications influencing BP; 6. Coronary heart disease, myocardial infarction or stroke within recent 6 months; 7. Atrial fibrillation or frequent arrhythmia; 8. Abnormal liver function exemplified as an increased alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBL) over the double of the upper limit of normal range; abnormal renal function exemplified as a serum creatinine ≥176 µmol/L; and plasma potassium ≥5.5 mmol/L or ≤3.5mmol/L; 9. Pregnant or lactating women; 10. Contraindications of angiotensin II receptor blocker or calcium channel blocker; 11. Other concomitant diseases which are considered not suitable to participate in the trial, such as thyroid diseases, acute infectious diseases, chronic mental diseases, tumor, etc.