DEPLIPIDO Study: Functional and Lipidomic Analysis of Plasma HDL in Patients With Depression Compared to Controls

Inclusion Criteria: * FOR PATIENTS WITH RECURRENT DEPRESSION : * Patient who has provided oral consent * Adult with moderate to severe depression according to DSM-5 criteria (Hamilton HDRS-17 score ≥ 18), with a number of depressive episodes ≥ 3 * PATIENTS PRESENTING WITH A FIRST DEPRESSIVE EPISODE * Patient who has provided oral consent * Adult with moderate to severe characterized depression according to DSM-5 criteria (Hamilton HDRS-17 scale score ≥ 18) presenting with a first depressive episode. * CONTROLS * Person who has provided oral consent * Adult who has never shown signs of depression Exclusion Criteria: * Person not affiliated with national health insurance * Person subject to a measure of legal protection (curatorship, guardianship) * Pregnant or breastfeeding women * Adult unable to express consent * Minors * Person with a metabolic syndrome (according to NCEP/ATP-III criteria: 3 of the following 5 criteria: Waist circumference ≥ 102 cm in males and ≥ 88cm in females, Triglycerides \> 1.50 g/L, HDL-Cholesterol \< 0.40 g/L in H, HDL-Cholesterol \< 0.50 g/L in F, Blood pressure ≥130/85mmHg, Fasting blood glucose ≥ 1.10 g/L), * Person with type 1 or type 2 diabetes, * Person with a mild depressive episode (HDRS-17\<18), * Person with concomitant antipsychotic treatment * Person with bipolar disorder, * Person with a moderate to severe alcohol use disorder according to DSM-5 criteria * Person with schizophrenia, * Person with a persistent delusional disorder, * Person with an autism spectrum disorder.