Exploration of the Cellular and Molecular Mechanisms in Patients Receiving Biotherapies Targeting the IL-23/IL-17 Axis in Cutaneous Psoriasis
Recruiting
Observational Study
Psoriasis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
90 (estimated)
Sponsor
Institut Pasteur · Industry
Who this trial is looking for
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This is a research study involving humans, of the interventional type with minimal risks and constraints (RIPH2). It is a monocentric, non randomized prospective study aiming to better understand the mechanisms of the response to anti-IL-23 biologics in psoriasis patients attending the dermatology department of hospital Cochin (APHP).
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
All patients:
* Adults (\>18 years)
* Presenting with cutaneous psoriasis
* Patients have signed an informed consent
* Beneficiary of the health insurance, except for the AME Only for patients of Group 1
* Patients require systemic treatment for psoriasis
* Patients are naïve t…
Inclusion Criteria:
All patients:
* Adults (\>18 years)
* Presenting with cutaneous psoriasis
* Patients have signed an informed consent
* Beneficiary of the health insurance, except for the AME Only for patients of Group 1
* Patients require systemic treatment for psoriasis
* Patients are naïve to biological therapies
Only for patients of Group 2:
* Patients requiring treatment with anti-IL-23 biologics (guselkumab, risankizumab, tildrakizumab) upon referent physician's decision.
* Patients are naïve to biological therapies or have received only one biologic, with a "wash-out" period of at least 4 months
Non inclusion Criteria:
For all :
* Patient is minor
* Patient is pregnant or breastfeeding
* Patient is immunocompromised
* Patient is under legal protection, curatorship, guardianship
* Patient refuses consent
* Patient is unable to comply with study requirements for geographic, social or psychiatric reason.
* Beneficiary of the AME Only for patients of Group 1
* Patient has received biologics Only for patients of Group 2
* Patient has a contraindication to the chosen biotherapy
* Patient has received biologics within the last 4 months
* Patient has been treated with 2 or more biologics
* Patient has already received an anti-IL-23 biologic
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