mRNA-3927 for Propionic Acidemia

A Study to Assess the Long-term Safety and Clinical Activity of mRNA-3927 in Participants Previously Enrolled in the mRNA-3927-P101 Study

Recruiting Phase 1 Phase 2 Interventional Study
Propionic Acidemia
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

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At a Glance
Age
1 and older
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
50 (estimated)
Sponsor
ModernaTX, Inc. · Industry
Who this trial is looking for

This trial is looking for people with propionic acidemia who have already participated in a previous study. Participants will receive mRNA-3927, and the study will assess its long-term safety.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have participated in Study mRNA-3927-P101.
  • I have completed the End of Treatment visit in Study mRNA-3927-P101.

You may not be able to join if

  • I am not expected to benefit from continued mRNA-3927 treatment, according to the doctor.
  • I have a medical condition that may put me at increased risk in this study.
  • I have had a liver or kidney transplant.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The main purpose of this study is to evaluate the long-term safety of mRNA-3927 administered to participants with propionic acidemia (PA) who have previously participated in Study mRNA-3927-P101 (NCT04159103).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Participated in Study mRNA-3927-P101. * Completed the EOT/ET visit in Study mRNA-3927-P101 and enroll in this study such that the first dose in this study is planned to be within 14±3 days of the last dose of mRNA-3927 in the mRNA-3927-P101 study. Exclusion Criteria: * Not e…
Contacts

Moderna WeCare Team

1-866-663-3762

WeCareClinicalTrials@modernatx.com

CONTACT