Shortened Antibiotic Treatment for Endocarditis
Accelerated Treatment of Endocarditis
Recruiting
Phase 4
Interventional Study
Endocarditis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 475 (estimated)
- Sponsor
- Herlev Hospital · Other
Who this trial is looking for
This trial is looking for adults with a specific type of heart infection called endocarditis. Participants will have their treatment duration based on how well they respond to initial therapy.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with left-sided infectious endocarditis
- I have had less than 14 days of relevant antibiotic treatment
- I have one of the following bacteria: streptococci, enterococcus faecalis, or staphylococcus aureus
- I am over 18 years old
You may not be able to join if
- I have known immune incompetency
- I have had a relapse of endocarditis in the past 6 months
- I am unable to give informed consent
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks one or more types of intravenously administered antibiotics. The long hospitalization increases several risks for the patient, including mental strain and increased loss of function. Furthermore, it poses a significant financial burden on the health systems. Current guidelines fail to use available clinic…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Admitted with left-sided infectious endocarditis (duke criteria)
* \< 14 days of relevant antibiotic treatment for endocarditis
* One of the following bacteria: Streptococci, enterococcus faecalis, staphylococcus aureus
* \> 18 years old
Exclusion Criteria:
* Known immune in…
Contacts
No contact information available.