Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity
Recruiting
N/A
Interventional Study
Physical Inactivity
Phosphate Overload
Visceral Obesity
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 80
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 124 (estimated)
- Sponsor
- University of Texas Southwestern Medical Center · Other
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About This Trial
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.
Exclusion …
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