Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Recruiting
N/A
Interventional Study
Diabetes Mellitus, Type 2
PreDiabetes
Insulin Resistance
Obesity
Nonalcoholic Steatohepatitis
Nonalcoholic Fatty Liver
Diet Modification
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 35 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 110 (estimated)
- Sponsor
- Stanford University · Other
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
This 12-week controlled diet and weight intervention study seeks to define the molecular pathways that link excess body weight to the development of insulin resistance (IR). Blood, adipose and stool are sampled at three timepoints; baseline, peak weight (4 weeks) and post weight loss to monitor changes in cellular processes. Additionally, direct insulin sensitivity testing, and radiological measur…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Age 35-65
* BMI 25-35 kg/m2
* Stable body weight
* Nondiabetic
Exclusion Criteria:
Patients with;
* diabetes
* major organ disease
* history of liposuction or bariatric surgery
* active eating or psychiatric disorder
* pregnancy or lactation, heavy alcohol use
* recent chan…
Contacts