Math Learning DisabilityChild DevelopmentDevelopmental DisabilityLearning DisabilitiesLearning DisabledLearning CurveMathematics DisorderDyscalculiaDyscalculia, PrimaryDyscalculia, AcquiredSpecific Learning Disorder, With Impairment in MathematicsIndividualityBehavior, ChildBehavior and Behavior MechanismsBehaviorDecision MakingNeuronal PlasticityCognitionCognition DisorderCognitive DysfunctionCognitive ChangeCognitive Impairment, MildCognitive Developmental DelayCognitive OrientationCognitive Delay, MildCognitive Deficits, MildCognitive AbnormalityNeuroscience
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
6 – 12
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
180 (estimated)
Sponsor
Stanford University · Other
Who this trial is looking for
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The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Elementary school aged children starting from first grade (6-12 years old)
2. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile perc…
Inclusion Criteria:
1. Elementary school aged children starting from first grade (6-12 years old)
2. IQ: Participants with a Full Scale IQ \> 70 on the Wechsler Abbreviated Scle of Intelligence (WASI-II).
3. Identification of Mathematical Learning Disabilities: Scores below the 35th percentile percentile on symbolic number processing test in Numeracy Screener and two or more Wechsler Individual Achievement Test (WIAT-IV) math subtests
4. Identification of typically developing children: Scores at or above the 35th percentile percentile on symbolic number processing test in Numeracy Screener and all WIAT-IV math subtests
5. Normal or corrected-to-normal vision and no hearing impairments
6. Inclusion in MRI scan session: Right-handed
Exclusion Criteria:
1. History of neurological or psychiatric disorder (i.e., schizophrenia, psychosis, depression, or attention deficit hyperactivity disorder.)
2. History of trauma involving head injury
3. Consistent psychiatric medications
4. Exclusion from MRI scan session: No major contraindication for magnetic resonance imaging (MRI) - braces, metal implants, pacemakers, vascular stents, metallic ear tubes, consistent exposure to metal, claustrophobia)
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