Exercise After COVID-19 Vaccination for Immune Response
Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress
Recruiting
N/AInterventional Study
Immunization
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 64
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
80 (estimated)
Sponsor
Iowa State University · Other
Who this trial is looking for
This trial is looking for adults aged 18 to 64 who regularly exercise and are planning to receive their first dose of a COVID-19 mRNA vaccine. Participants will either do a light to moderate exercise session after vaccination or continue with their usual daily routine.
Are You a Good Fit for This Trial?
You may be able to join if
I can donate a small amount of blood.
I plan to receive an initial mRNA COVID-19 vaccine.
I am between 18-64 years of age.
I regularly exercise two or more times per week.
I can safely perform 90 minutes of light to moderate exercise.
You may not be able to join if
I am currently pregnant.
I weigh less than 110 pounds.
I have a condition that affects my ability to exercise safely.
I cannot receive the mRNA COVID-19 vaccine.
I take medication that affects my immune response.
I have an immune disorder.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to evaluate the extent to which a single session of light to moderate intensity exercise performed within 30 minutes after receiving either the initial dose of COVID-19 mRNA vaccine may modify the immune response to vaccination, and identify potential underlying mechanisms using gene expression and metabolite analysis. A secondary goal is to establish whether psychosoc…
The purpose of this study is to evaluate the extent to which a single session of light to moderate intensity exercise performed within 30 minutes after receiving either the initial dose of COVID-19 mRNA vaccine may modify the immune response to vaccination, and identify potential underlying mechanisms using gene expression and metabolite analysis. A secondary goal is to establish whether psychosocial factors are associated with immune response to vaccination. Participants will be randomized to either a 90-minute light to moderate intensity exercise session or daily routine as usual (no exercise) after receiving their initial COVID-19 mRNA vaccine. If assigned to exercise, the exercise will begin within 30 minutes after receiving the vaccine and will consist of a brisk walk and/or jog supervised by study personnel. Blood will be collected from participants prior the initial dose, two weeks after the initial dose, one week after the second dose if the individual receive the two-dose vaccine regiment or one month after the initial dose if the individual receives a one-dose vaccine regimen, and three, six, and 12 months following the initial dose. . Side effects will be measured for three days post-vaccination. Antibody and cell-mediated immune response to the vaccine will be measured in blood samples. Gene expression profiles will be analyzed by single cell RNA sequencing. Serum metabolites will be assessed to align with immune measures. Participants will be asked to complete surveys to measure physical activity history, psychosocial stress, resilience, and depression. The hypotheses of this study are: 1) a single session of exercise which take place shortly after receiving either the initial dose or the booster dose of COVID-19 will increase antibody and T cell response to the vaccine and will be associated with differentially expressed genes and an altered metabolite profile, and 2) higher levels of reported stress, and lower levels of resilience will be associated with a reduced antibody and T cell response to the vaccine.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Able to donate a small amount of blood,
* Planning to receive an initial mRNA Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine,
* Between 18-64 years of age,
* Regularly participate in some form of exercise two or more times per week, including at least one ses…
Inclusion Criteria:
* Able to donate a small amount of blood,
* Planning to receive an initial mRNA Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine,
* Between 18-64 years of age,
* Regularly participate in some form of exercise two or more times per week, including at least one session equal to or greater than 50 minutes exercise sessions or walk three or more times per week with at least one session equal to or greater than 50 minutes.
* Can safely perform 90 minutes of light to moderate intensity exercise (walk, walk/jog, or jog) based on American College of Sports Medicine exercise participation guidelines
Exclusion Criteria:
* Currently pregnant
* Weigh less than 110 pounds.
* Presence of any conditions that could significantly impact the ability to exercise safely, or unable to receive the mRNA COVID-19 vaccine
* Taking medication that significantly impact immune response or the presence of an immune disorder.
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