No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
200 (estimated)
Sponsor
University of Alabama at Birmingham · Other
Who this trial is looking for
This trial is looking for adults to participate in a study about hormones from the heart that can help with heart health and metabolism. Participants will need to complete exercise and glucose tests to help researchers understand how these hormones work.
Are You a Good Fit for This Trial?
Rules you outDiabetesCardiovascular diseases
You may be able to join if
I am 18 years or older
I can provide a sample of my genetic material
I agree to follow the study rules
You may not be able to join if
I am under 18 years old
My body mass index (BMI) is over 45
My blood pressure is higher than 140/90
I take more than 2 medications for high blood pressure
I have a history of diabetes
I have had any heart-related health issues
I am pregnant, breastfeeding, or can become pregnant without using birth control
I cannot exercise on a treadmill
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to…
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes and poor cardiometabolic health. Obese and Black individuals have \~30% lower levels of NP and are at a greater risk of developing cardiovascular (CV) events as compared to lean and White counterparts. Some people have common genetic variations that cause them to have \~20% lower NP levels. Similar to other low NP populations, these individuals with low NP genotype (i.e., carrying a common genetic variation called rs5068) are at a greater risk of developing cardiometabolic diseases. By understanding the NP response following the exercise challenge and the glucose challenge in individuals with genetically lower NP levels will help us understand how to improve cardiometabolic health in them.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Adults: Age more than or equal to 18; an equal number of Males and Females
* Consent to the collection of genetic material
* Willing to adhere to the study protocol
Exclusion Criteria:
* Age \<18, at screening.
* BMI \>45 kg/m2.
* Blood pressure more than 140/90 mmHg.
* Part…
Inclusion Criteria:
* Adults: Age more than or equal to 18; an equal number of Males and Females
* Consent to the collection of genetic material
* Willing to adhere to the study protocol
Exclusion Criteria:
* Age \<18, at screening.
* BMI \>45 kg/m2.
* Blood pressure more than 140/90 mmHg.
* Participants who are taking more than 2 hypertension medications.
* History of diabetes or fasting plasma glucose \>126 mg/dl or HbA1C\>=6.5% or prior treatment with antidiabetic medication.
* Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia)
* Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence);
* Estimated GFR \< 60 ml/min/1.73 m2; albumin creatinine ratio ≥30 mg/g
* Hepatic Transaminase (AST and ALT) levels \>3x the upper limit of normal
* Anemia (men, Hct \< 38%; women, Hct \<36%)
* Inability to exercise on a treadmill
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