mTOR as Mediator of Insulin Sensitivity Study
Recruiting
N/A
Interventional Study
Insulin Sensitivity
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 22 – 35
- Sex
- Male
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 10 (estimated)
- Sponsor
- University of Copenhagen · Other
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About This Trial
The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. This will be investigated in young healthy male subjects by administering the pharmacological mTOR inhibitor Rapamycin in a crossover blinded experimental setup known to enhance muscle insulin sensitivity following one-legged knee-extensor exercise.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Healthy persons (no known disease) without diabetes in the family
* No use of medications
* Non-smokers
* Men
* Age 22-35 years
* Physical activity level (VO2peak) between 30-50 mL O2/min/kg
* BMI between 18.0 and 25.0
Exclusion Criteria:
* Women
* Physical activity (e.g., r…
Contacts