Bone Marrow Study on Clonal Hematopoiesis
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Recruiting
Observational Study
Osteoporosis
Osteoarthritis, Hip
Hip Fractures
Clonal Hematopoiesis of Indeterminate Potential
Aging
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 55 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 24 (estimated)
- Sponsor
- Imelda Hospital, Bonheiden · Other
Who this trial is looking for
This trial is looking for older adults, 65 years and above, who are having hip surgery. Participants will provide blood and bone marrow samples for research on certain genetic changes and their effects.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 65 years old or older
You may not be able to join if
- I have a known blood condition like leukemia or cancer
- I am unable to provide written informed consent
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations. Combined single-cell transcriptomics and mutation-specific single-cell genotyping (biotin-PCR using mutation-targeted primers followed by sequencing) will subsequently be performed. The gene expression p…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 65 years and older
Exclusion Criteria:
* known haematological condition (myelodysplasia, leukemia, cancer)
* inability to provide written informed consent
Contacts