Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection

Inclusion Criteria: 1. Age ≥ 18 years; 2. Ability to provide written informed consent; 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1; 4. T1-T4 (T3,T4 multifocal) N0M0 NSCLC who are planned for complete surgical resection; 5. Tumour size must be at least 1 cm (unidimensional) and have at least some solid component on imaging; 6. Surgical tumour formalin-fixed, paraffin-embedded (FFPE) specimens for ctDNA studies are required. Exclusion Criteria: 1. Prior radiation, surgery or chemotherapy for the current diagnosis of NSCLC is not permitted. 2. Incomplete surgical resection. Participants who had pre-operative ctDNA samples taken but subsequently do not have a complete surgical resection would not qualify for post-operative ctDNA testing. 3. Concurrent enrolment in a therapeutic study using drug or radiation therapy. Enrolment in observational, diagnostic or studies of novel surgical techniques will be allowed. 4. Concurrent active malignancy or other invasive malignancy within previous 2 years. Non-invasive malignancies (i.e., cervical carcinoma in situ, in situ prostate cancer, non-melanomatous carcinoma of the skin, ductal carcinoma in situ of the breast that has been surgically cured) are excluded from this definition. 5. Pregnancy.