Brain Health Study for Youth with Weight Concerns
Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)
Recruiting
Observational Study
Type2 Diabetes
Type 2 Diabetes Mellitus in Obese
Dysglycemia
Microvascular Complications
Brain Structure
Obesity, Childhood
Diabetes in Adolescence
Inflammation
Insulin Resistance
Overweight, Childhood
Cognitive Decline
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 12 – 17
- Sex
- Any
- Study type
- Observational
- Participants needed
- 117 (estimated)
- Sponsor
- Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for young people aged 12 to 19 who have a normal weight, are overweight, or have obesity and are at risk for type 2 diabetes. Participants will undergo brain scans and cognitive tests to help understand how weight and blood sugar levels affect brain health.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 12 and 19 years old.
- I have a body mass index (BMI) that indicates normal weight, overweight, or obesity.
- I am otherwise healthy except for obesity.
- I can weigh less than 450 pounds.
- I can lie flat for an MRI scan.
- I can do cognitive testing.
- I speak and understand English.
You may not be able to join if
- I have a form of obesity caused by a syndrome.
- I have had bariatric surgery.
- I have received insulin treatment for type 2 diabetes.
- I have metal in my body or claustrophobia that prevents me from having an MRI.
- I wear braces or am pregnant or breastfeeding.
- I cannot participate in cognitive testing due to sensory or language issues.
- I have significant psychiatric disorders.
- I have a history of neurological issues.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will dete…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 12-17 yrs. old at visit 1, 12-19 yrs. old at visit 2, Tanner II or above (determined through an exam by a pediatric endocrinologist or certified nurse practitioner trained in pediatric endocrinology), otherwise healthy except for obesity, \<450 lbs. (due to MRI scanner limits)…
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