Atorvastatin for Obstructive Sleep Apnea
Vascular Endothelial Dysfunction in Sleep Apnea
Recruiting
Phase 1
Interventional Study
Obstructive Sleep Apnea of Adult
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 110 (estimated)
- Sponsor
- Columbia University · Other
Who this trial is looking for
This trial is looking for adults who have recently been diagnosed with obstructive sleep apnea and have not yet started treatment with CPAP. Participants will take atorvastatin for 4 weeks to see if it helps reduce inflammation linked to their condition.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old
- I have been diagnosed with obstructive sleep apnea
You may not be able to join if
- I have a history of heart disease
- I have heart failure
- I've had a stroke
- I have diabetes
- I have cancer
- I have chronic lung disease
- I have chronic kidney disease
- I have muscle pain or fatigue
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
This double-blind placebo-controlled parallel group randomized study design will be used to test whether 4 weeks of atorvastatin 10 mg daily reduces levels of inflammatory markers in OSA patients treated with CPAP (standard of care). The purpose of this study is to investigate: 1) whether statins reduce endothelial inflammation and pro-thrombotic conditions in OSA, including in patients adherent t…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged ≥18 years
* Newly diagnosed with obstructive sleep apnea (OSA) who were never treated with CPAP. OSA is defined as apnea-hypopnea index (AHI) ≥5 events/hour of sleep.
Exclusion Criteria:
* A history of coronary artery disease, heart failure, stroke, diabetes, malignancy…
Contacts