Fully Automated High-Throughput Quantitative MRI of the Liver
Recruiting
Observational Study
HealthyIron OverloadLiver Fat
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
7 and older
Sex
Any
Study type
Observational
Participants needed
200 (estimated)
Sponsor
University of Wisconsin, Madison · Other
Who this trial is looking for
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Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this research is to see if a new automated magnetic resonance imaging (MRI) method will be able to improve the images taken of the liver. Participants will have either known or suspected liver disease, known or suspected iron overload syndrome, or be a healthy adult. Participants will be in the research study for one day.
Trial Locations
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Eligibility Criteria
Eligibility Criteria for Substudies 1, 2, 4, 5
Inclusion Criteria:
* Age 18 years or older
Exclusion Criteria:
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report du…
Eligibility Criteria for Substudies 1, 2, 4, 5
Inclusion Criteria:
* Age 18 years or older
Exclusion Criteria:
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
Eligibility Criteria for Substudy 3
Inclusion Criteria:
* Age 7 years or older
* One of:
* Known or suspected liver iron overload
* Known or suspected elevated liver fat
Exclusion Criteria:
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
* The subject has their own prescription for the medication.
* The informed consent process is conducted prior to the self-administration of this medication
* They come to the research visit with a driver
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
Eligibility Criteria for Substudy 6
Inclusion Criteria:
* Age 7 years or older
* Scheduled for a clinical abdominal MRI exam
Exclusion Criteria:
* Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
* Sedation required for MRI
* Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
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