Labetalol vs Nifedipine for Postpartum Hypertension

Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial

Recruiting Phase 4 Interventional Study
Postpartum Preeclampsia Hypertension in Pregnancy
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
19 and older
Sex
Female
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
600 (estimated)
Sponsor
Nebraska Methodist Health System · Other
Who this trial is looking for

This trial is looking for women who have high blood pressure after giving birth. Participants will be treated with either Labetalol or Nifedipine to see which works better to reduce complications and hospital readmissions.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 24 weeks pregnant or more
  • I have high blood pressure defined as 140 or higher for the top number or 90 or higher for the bottom number measured two times
  • I am admitted for delivery by cesarean or vaginal delivery

You may not be able to join if

  • I have a history of moderate persistent asthma
  • I have a history of coronary artery disease
  • I have a history of heart failure
  • I have a history of AV heart block
  • I have a history of pulmonary edema
  • I cannot take either Nifedipine or Labetalol
  • My heart rate is below 60 or above 110
  • My native language is neither English nor Spanish

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: Any patient admitted for delivery by cesarean or vaginal delivery at 24 weeks gestation or greater with hypertension(HTN). Hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 h…
Contacts

Todd Lovgren, MD

4028151970

todd.lovgren@nmhs.org

CONTACT

Joshua Dahlke, MD

4028151970

joshua.dahlke@nmhs.org

CONTACT