Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes
Recruiting
N/A
Interventional Study
Continuous Glucose Monitoring
Oral Glucose Tolerance
Insulin Sensitivity
Inflammatory Markers
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 40 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 30 (estimated)
- Sponsor
- Virginia Polytechnic Institute and State University · Other
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About This Trial
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-c…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 40+ years
* Prediabetic (fasting glucose concentration of 100-125 mg/dL, 2-hour oral glucose tolerance test glucose concentration of 140-199 mg/dL, or a HbA1c value of 5.7% to 6.4%)
* Weight stable for previous 6 months (±2 kg)
* BMI \<40 kg/m2
* Sedentary to recreationall…
Contacts