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At a Glance
Age
65 and older
Sex
Any
Study type
Observational
Participants needed
1,500 (estimated)
Sponsor
University Hospital Freiburg · Other
Who this trial is looking for
This trial is looking for older adults aged 65 and over who have been diagnosed with advanced head and neck cancer. Participants will receive a combination of chemotherapy and radiotherapy to assess treatment outcomes.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with advanced head and neck cancer
I am 65 years or older
I started my primary treatment since 2005
You may not be able to join if
I have had previous head and neck cancers
I have received previous radiotherapy in the head and neck area
I have distant metastases when starting treatment
I have head and neck cancer in the nasopharynx or salivary glands
I have head and neck cancer with an unknown primary tumor
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiothe…
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* definitive (chemo-)radiotherapy of locoregionally advanced (cT3-4 and/or cN+) head-and-neck squamous cell carcinomas (HNSCC) of the oral cavity, oropharynx, hypopharynx or larynx
* primary treatment since 2005
* age ≥65 years at the time of (chemo-)radiotherapy
Exclusion Crit…
Inclusion Criteria:
* definitive (chemo-)radiotherapy of locoregionally advanced (cT3-4 and/or cN+) head-and-neck squamous cell carcinomas (HNSCC) of the oral cavity, oropharynx, hypopharynx or larynx
* primary treatment since 2005
* age ≥65 years at the time of (chemo-)radiotherapy
Exclusion Criteria:
* adjuvant (chemo-)radiotherapy
* history of previous head-and-neck cancers or radiotherapy in the head-and-neck region
* distant metastases at (chemo-)radiotherapy initiation (cM1)
* HNSCCs of the nasopharynx, salivary glands, skin or with unknown primary
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