Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases

Recruiting N/A Interventional Study
Brain Metastases
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
130 (estimated)
Sponsor
Haaglanden Medical Centre · Other
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About This Trial

Randomized phase II trial. The study aims to investigate a different and potentially safer radio therapeutic treatment method for brain metastases. The current standard of stereotactic radiotherapy (SRT) in one or three fractions is compared to fractionated stereotactic radiotherapy (fSRT) in five fractions.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years * At least one brain metastasis of large cell cancer suitable for SRT * Karnofsky Performance Status ≥ 70 * Ability to provide written informed consent * New brain metastases during follow-up after surgery allowed (when outside of resection cavity area) * New br…
Contacts

Jaap D Zindler, MD, PhD

+31-88-9792013

j.zindler@haaglandenmc.nl

CONTACT

Mirjam Mast, PhD

+31-88-9792013

m.mast@haaglandenmc.nl

CONTACT