No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
20 and older
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Prevention
Participants needed
2,890 (estimated)
Sponsor
Takeshi Morimoto · Other
Who this trial is looking for
This trial is looking for patients with chronic coronary syndromes who cannot have heart surgery. Participants will take aspirin and help researchers learn about its effects and safety in this group.
Are You a Good Fit for This Trial?
Rules you outHistory of strokeAtrial fibrillation
You may be able to join if
I have chronic coronary syndromes with at least 50% narrowing in my coronary arteries.
I cannot have coronary heart surgery.
I can give my consent to participate.
You may not be able to join if
I have had an acute coronary syndrome in the past.
I have had a heart procedure like PCI or CABG.
I have major narrowing in my left main coronary artery.
I must take aspirin for another reason.
I am on blood-thinning treatment other than aspirin.
I have atrial fibrillation.
I had a stroke in the last six months.
I am scheduled for major surgery where I'll need to stop taking aspirin.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to evaluate the efficacy and safety aspirin in patients with chronic coronary syndromes without revascularization.
Trial Locations
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Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Patients with chronic coronary syndromes with ≧50% diameter stenosis in one or more major coronary vessels/major branches on coronary CT or coronary angiography but not eligible for coronary revascularization
* Patients for whom consent can be obtained
Exclusion Criteria:
* …
Inclusion Criteria:
* Patients with chronic coronary syndromes with ≧50% diameter stenosis in one or more major coronary vessels/major branches on coronary CT or coronary angiography but not eligible for coronary revascularization
* Patients for whom consent can be obtained
Exclusion Criteria:
* Patients with history of acute coronary syndromes (ACS)
* Patients with history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG)
* Patients with left main trunk stenosis (≥50%)
* Patients for whom aspirin administration is mandatory
* Patients undergoing antithrombotic therapy other than aspirin
* Patients with atrial fibrillation
* Patients with history of stroke within six months
* Patients scheduled for major surgical procedures that will require aspirin discontinuation
* Patients with contraindication of aspirin
* Patients expected to have a prognosis of 1 year or less due to comorbidities
* Women of child-bearing potential or women who have a positive pregnancy test at enrolment or randomization
* Patients who are judged by attending physicians to be inappropriate to participate in this study
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