No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
50 – 75
Sex
Female
Study type
Interventional
Purpose
Basic Science
Participants needed
120 (estimated)
Sponsor
Florida State University · Other
Who this trial is looking for
This trial is looking for postmenopausal women who are obese and have prediabetes. Participants will engage in resistance training to see if it helps improve fat metabolism and prevent type 2 diabetes.
Are You a Good Fit for This Trial?
You may be able to join if
I am a woman
I am aged 50 to 75 years
I am obese with a BMI between 30 and 50
I have prediabetes
I am sedentary and do not exercise regularly
I do not smoke
I have not taken hormone replacement therapy in the last two years
You may not be able to join if
I do resistance or endurance training for more than 20 minutes, 2 days a week
My resting blood pressure is above 140/90 mmHg
I have type 1 or type 2 diabetes
I have a medical condition where exercise is not recommended
I have or have had cancer, heart disease, or breathing problems
I have uncontrolled thyroid, liver, or kidney issues
I take medications that affect how my body processes fats
I have a musculoskeletal problem that prevents me from exercising
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the…
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Women
* Postmenopausal (50-75 yrs.)
* Obese (BMI 30-50 kg/m2)
* Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
* Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a we…
Inclusion Criteria:
* Women
* Postmenopausal (50-75 yrs.)
* Obese (BMI 30-50 kg/m2)
* Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
* Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
* Non-smokers
* No hormone replacement therapy for at least the past two years.
Exclusion Criteria:
* Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
* Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
* Type 1 or type 2 diabetes
* Medical problems in which exercise is contraindicated, such as chronic infections
* History of, or currently presentation with, cancer, cardiovascular or respiratory disease
* Uncontrolled thyroid dysfunction, liver or renal dysfunction
* Taking any medication affecting lipid metabolism
* Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
* Smokers and those with diagnosed eating disorders
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