Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
20 – 65
Sex
Any
Study type
Observational
Participants needed
62 (estimated)
Sponsor
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Other
Who this trial is looking for
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This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion
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Eligibility Criteria
Inclusion Criteria:
* age 20-65 years;
* ≥ 6 years of education;
* right-handed;
* complete entire cognitive function tests;
* adrenal lesions ≥ 1 cm in diameter;
* patients with non-functioning adrenal adenomas;
* patients with autonomous cortisol secretion.
Exclusion Criteria:
* \< 6 years of e…
Inclusion Criteria:
* age 20-65 years;
* ≥ 6 years of education;
* right-handed;
* complete entire cognitive function tests;
* adrenal lesions ≥ 1 cm in diameter;
* patients with non-functioning adrenal adenomas;
* patients with autonomous cortisol secretion.
Exclusion Criteria:
* \< 6 years of education;
* age \< 20 years or \> 65 years;
* maximum diameter of AI \<1cm;
* active malignancies;
* with a history of thyroid disease;
* with a history of acute infection in the last month;
* central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;
* contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;
* adrenal tuberculosis;
* suspected or diagnosed adrenocortical carcinoma;
* unable to complete entire cognitive function tests;
* current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;
* clinical Cushing syndrome;
* Cushing disease;
* primary hyperaldosteronism;
* pheochromocytoma;
* severe impairment of heart, liver, kidney and other organs;
* pregnant and lactating women
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