MicroRNA Regulation of Chronic Inflammation During Aging

Inclusion Criteria: 1. Age between 18 - 35y; 65y and older 2. BMI: \<30 kg/m2 3. Ability to sign informed consent 4. For older participant group: Clinical Frailty Scale score \< 3 and Mini-Cog score \> 3 5. Good general medical health, ambulatory and in independent living setting Exclusion Criteria: * History of cardiovascular disease (e.g., CHF, CAD, MI, CVA) * History of endocrine or metabolic disease such as hypo/hyperthyroidism and diabetes (Treated hypo/hyperthyroid for at least 6 months will be permitted) * History of kidney disease or failure (CKD \> stage 4) * History of vascular disease * Uncontrolled hypertension - Elevated systolic pressure \>150 or a diastolic blood pressure \> 100 * Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma * Chronic systemic corticosteroid use (≥ 2 weeks) within 4 weeks of enrollment and for study duration (intra-articular/topical/inhaled therapeutic or physiologic doses of corticosteroids will be permitted) * Chronic anti-inflammatory medication use (≥ 2 weeks) within 4 weeks of enrollment * Chronic inflammatory conditions (e.g., Rheumatoid Arthritis, Crohn's, fibromyalgia, lupus, colitis) HIV, Hepatitis B and C * History of stroke with motor disability * A recent history (\<12 months) of GI bleed * History of liver disease or AST/ALT 2 times above the normal limit * History of respiratory disease (acute upper respiratory infection, history of chronic lung disease) * Current smokers or current tobacco use * Current pregnancy as determined by positive pregnancy test * Any staff members who report directly to the principal investigators.