Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma

Recruiting Phase 1 Interventional Study
Neuroblastoma Refractory Neuroblastoma Relapsed Neuroblastoma Relapsed Osteosarcoma Refractory Osteosarcoma
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
12 Months and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
24 (estimated)
Sponsor
Emory University · Other
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About This Trial
The goal of this clinical trial is to determine the maximum tolerated dose (MTD) and recommended Phase II dose (RP2D) of allogeneic expanded γδ T cells when delivered with Dinutuximab, temozolomide, irinotecan, and zoledronate in children with refractory or recurrent neuroblastoma or refractory/ relapsed osteosarcoma as well as to define the toxicities of allogeneic expanded γδ T cells when delive…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Patients must be ≥ 12 months of age at the time of enrollment in the study. * Diagnosis: Histological confirmation of neuroblastoma or ganglioneuroblastoma at initial diagnosis. (Bone marrow samples with positive catecholamines are acceptable as confirmation of neuroblastoma) …
Contacts

Kelly Goldsmith, MD

(404) 727-2655

kgoldsm@emory.edu; mpactcto@choa.org

CONTACT