Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA
Recruiting
N/A
Interventional Study
Primary Aldosteronism
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 122 (estimated)
- Sponsor
- Queen Mary University of London · Other
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About This Trial
The primary objective of WAVE is to test the hypothesis that thermal ablation (microwave or RFA) is non-inferior to surgery in the biochemical (and if so, in the clinical) cure of unilateral PA, according to the international consensus PASO criteria.
Secondary objectives are to determine whether either intervention is superior to the other in relation to the following outcomes. Where no superiori…
Trial Locations
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Eligibility Criteria
Inclusion criteria (all of):
* Age \> 18 years
* Primary aldosteronism diagnosed according to international guidelines
* Unilateral disease by AVS or PET-CT criteria
* Ipsilateral radiological abnormality with benign imaging characteristics and technically amenable to both thermal ablation and surg…
Contacts