Assessing Effect of Spinal Cord Stimulation on Pain and Quality of Life With Chemotherapy-Induced Peripheral Neuropathy

Inclusion Criteria: * Adult patients greater than or equal to 18 years of age who have been clinically diagnosed with CIPN for greater than six months after stopping chemotherapy * Average pain intensity \>= 5 on 11-point numeric rating scale (NRS) in the lower extremities at enrollment * Failed conventional medication management with at least two neuropathic pain medications * Have electrophysiological evidence of length-dependent peripheral neuropathy * Underwent a 10-kHz spinal cord stimulator trial for a primary indication of CIPN and reported a successful trial of at least 75% reduction in pain intensity * Have stable neurological status * Be on a stable analgesic regimen * Be an appropriate candidate for surgical procedures required in this study * Be able to read and understand English-written questionnaires and sign an informed consent form in English * Be willing and capable of giving informed consent * Be willing and able to complete study-related requirements, procedures, and visits Exclusion Criteria: * Patient refusal to be included in study * Presence of lower limb mononeuropathy * History of lower limb amputation or ulceration * Presence of another painful condition that is unrelated to CIPN and that is not intended to be treated in this study * Body mass index (BMI) \>= 40 * Omeprazole (OME) \> 120 mg * Progressive neurological disease (multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, rapidly progressive arachnoiditis, brain or spinal cord tumor, central deafferentation syndrome, complex regional pain syndrome, acute herniating disc, severe spinal stenosis) * Certain comorbidities: coagulation/bleeding disorders, diminished capacity from cardiac/pulmonary disease * Obtaining another interventional procedure unrelated to SCS to treat limb pain * Have ongoing metastatic malignant neoplasm or untreated local malignant neoplasm. Included patients must be deemed as in remission per discretion of treating oncologist * Have a life expectancy of less than one year * Have untreated addiction or dependency to medications, alcohol, or illicit drugs * Have active, disruptive, and/or unstable psychological or psychiatric disorder