Assessment of the Ocular Microbiome in Health and Disease
Recruiting
Observational Study
Microbial ColonizationEye DiseasesOphthalmopathy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
500 (estimated)
Sponsor
Vanderbilt University Medical Center · Other
Who this trial is looking for
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The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
We will include subjects who meet all of the following criteria:
* 18 years of age or older
* Provide informed consent
* Cohort A - normal eyes with no ocular disease
* Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled …
Inclusion Criteria:
We will include subjects who meet all of the following criteria:
* 18 years of age or older
* Provide informed consent
* Cohort A - normal eyes with no ocular disease
* Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
* Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
* Cohort D - Dry AMD (age related macular degeneration)
* Cohort E - Wet AMD
* Cohort F - diabetic retinopathy
Exclusion Criteria:
We will exclude subjects who meet all of the following criteria:
* Prior ocular disease either of the anterior or posterior segment
* Any medical comorbidities except well controlled DH and HTN
* Unable to follow up with study procedures as described
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