No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
21 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
30 (estimated)
Sponsor
University of Arizona · Other
Who this trial is looking for
This trial is looking for people who have language difficulties caused by a stroke or dementia. Participants will undergo a language-based treatment to see how it affects their communication skills and brain patterns.
Are You a Good Fit for This Trial?
You may be able to join if
I have language difficulties caused by a stroke or dementia.
I have a medical diagnosis of primary progressive aphasia.
I am a native English speaker.
I have normal or corrected vision and hearing.
I can safely undergo an MRI.
You may not be able to join if
I have a mood, anxiety, or substance abuse disorder.
I have certain metallic implants that might affect MRI quality.
I have another neurological disorder like epilepsy or Parkinson's.
I have any condition that would prevent me from safely having an MRI.
I suffer from significant claustrophobia.
I am currently pregnant.
I have a history of seizures in the past year.
I have had brain surgery in the past.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This impairment is seen in many aspects of language, including understanding, speaking, reading and writing. It is estimated that about 2 million individuals are currently living with aphasia in the United States. Further, about 200,000 Americans a…
Aphasia is an acquired impairment of language, that commonly results from damage to language areas in the brain (typically the left side of the brain). This impairment is seen in many aspects of language, including understanding, speaking, reading and writing. It is estimated that about 2 million individuals are currently living with aphasia in the United States. Further, about 200,000 Americans acquire aphasia every year (National Aphasia Association, 2020). Aphasia poses significant impact on the affected individuals and their families. Behavioral treatments that target language deficits have been shown to enhance overall communication skills and life satisfaction among individuals with aphasia. Although there is evidence that suggests that treatment is efficacious for individuals with aphasia, the extent of improvement long-term coupled with the neural patterns among those individuals are largely unknown. The current study aims to investigate the efficacy of language-based treatment and its corresponding neural patterns.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Present with speech-language impairment (aphasia) caused by stroke or dementia
2. A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician
3. Are native speakers of English
4. Present with no contraindications for MRI
5. Have adequate (normal or …
Inclusion Criteria:
1. Present with speech-language impairment (aphasia) caused by stroke or dementia
2. A medical diagnosis of primary progressive aphasia (PPA) by a neurologist or physician
3. Are native speakers of English
4. Present with no contraindications for MRI
5. Have adequate (normal or corrected to normal) vision and hearing
Exclusion Criteria:
1. Individuals diagnosed with mood, anxiety, psychotic or substance abuse disorders.
2. Individuals with highly magnetizable metallic implants, including certain dental work, may be excluded due to image quality in MRI.
3. Individuals with other neurological disorders besides the ones of interest for the study (e.g., epilepsy, Multiple Sclerosis, Parkinson's Disease)
4. Individuals with contraindications for MRI. This includes but is not limited to pacemakers, metallic cardiac pumps, valves, magnetic materials such as surgical clips, implanted electronic perfusion pumps, or any other condition that would preclude proximity to a strong magnetic field.
5. Individuals suffering from clinically significant claustrophobia
6. Severe systemic disease (e.g., renal failure)
7. Poor overall health
8. Individuals who are pregnant
9. Individuals with a history of epileptic activity in the past 12 months
10. Individuals with a personal or family history of epilepsy or other seizure disorders will not be included in the study.
11. Individuals who have had a brain surgery in the past
12. Individuals with implanted metallic skull plates or intracranial implants
13. Individuals with skin lesions or skull damage
14. Individuals who have a history of excessive use of alcohol or drugs
15. Individuals with premorbid psychiatric disease affecting communication
16. Individuals with severe non-linguistic cognitive disturbances impeding language therapy
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