Genomic Predictors of Recurrent Pregnancy Loss

Cohort A - Fetal Intolerome Cohort Inclusion Criteria: * Women with loss of a current singleton pregnancy at \< 20 0/7 weeks gestation, documented by ultrasonography or histopathological examination * History of one or more prior pregnancy losses * Euploid current pregnancy confirmed by karyotype, microarray, or STORK (Short-read Transpore Rapid Karyotyping) sequencing Note: A limited number of aneuploid losses will be included as part of the pilot phase Exclusion Criteria: * History of parental karyotype abnormalities * History of antiphospholipid antibody syndrome * Evidence of uncontrolled diabetes * Evidence of uncontrolled thyroid disease * History of autoimmune disease related to pregnancy loss (e.g., systemic lupus erythematosus, rheumatoid arthritis) * History of uterine anomalies * History of cervical insufficiency Cohort B - Maternal Effect Gene Cohort Inclusion Criteria: \- Women with a history of three or more pregnancy losses of unknown cause, with or without a liveborn child Exclusion Criteria: \- Known etiology for pregnancy loss