Cannabidiol for Anxiety in Bipolar Disorder

Assessing the Impact of Cannabidiol for Anxiety and Depression in Bipolar Disorder

Recruiting Phase 2 Interventional Study
Bipolar Disorder
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
25 (estimated)
Sponsor
Mclean Hospital · Other
Who this trial is looking for

This trial is looking for adults aged 18 to 65 with bipolar disorder and anxiety. Participants will take a high-CBD product for 4 weeks to see if it helps with their anxiety.

Are You a Good Fit for This Trial?
Must not be taking ValproateDivalproex
Rules you out Serious medical illnessNeurological disorderEating disorder

You may be able to join if

  • I can give my consent to participate.
  • I am between 18 and 65 years old.
  • I speak English fluently.
  • I have been diagnosed with bipolar disorder.
  • I experience moderate or more anxiety.
  • I am stable on my current medications.

You may not be able to join if

  • I am not fluent in English.
  • I have a current substance use disorder.
  • I have a current or past psychotic disorder.
  • I have thoughts of suicide.
  • I am currently experiencing a manic or depressive episode.
  • I have had a head injury that caused loss of consciousness for more than 5 minutes.
  • I currently use cannabinoid products.
  • I am pregnant or breastfeeding.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

Preliminary data have suggested that cannabidiol (CBD) may have a number of clinical benefits, including anti-anxiety and antidepressant properties. This study is a pilot open-label clinical trial assessing a custom-formulated high-CBD product over the course of 4 weeks in patients with bipolar disorder who experience anxiety.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Provides informed consent * Between the ages of 18-65 * Fluent in English * Meets DSM-5 criteria for bipolar disorder (type I or II) * Experiences at least moderate levels of anxiety (as evidenced by self-reported rating scales) * On a stable pharmacotherapeutic regimen Exclu…
Contacts

Rosemary Smith, B.S.

617-855-3338

CBDstudy@mclean.harvard.edu

CONTACT