Vaginal Estrogen for Breastfeeding Sexual Dysfunction

Postpartum Vaginal Estrogen for Breastfeeding Patients

Recruiting Phase 4 Interventional Study
Breastfeeding Postpartum Sexual Dysfunction Vaginal Atrophy
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 50
Sex
Female
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
University Hospitals Cleveland Medical Center · Other
Who this trial is looking for

This trial is looking for breastfeeding individuals who are experiencing sexual dysfunction after giving birth. Participants will use vaginal estrogen cream to see if it helps improve their sexual function compared to those who do not use the cream.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 18 years old or older
  • I am sexually active
  • I had a single baby at term (37 weeks)
  • I plan to breastfeed or pump during the study
  • I successfully breastfed or pumped after a previous pregnancy
  • I am between 6 weeks and 6 months postpartum
  • I can give my consent in English
  • I do not meet any exclusion criteria

You may not be able to join if

  • I had a premature birth
  • I have experienced perinatal death
  • I have had difficulty breastfeeding in the past
  • I had a 3rd or 4th degree perineal tear
  • I have a history of breast cancer or estrogen-sensitive conditions
  • I currently have or have had blood clot issues like DVT or PE
  • I have an allergic reaction to estrogen
  • I have liver disease or issues with certain blood proteins

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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About This Trial

Sexual dysfunction is very common in the postpartum period and is more common in people who breastfeed or pump. This research study was designed to help determine whether postpartum patients who use vaginal estrogen cream while breastfeeding have improved sexual function compared to postpartum patients who do not.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age 18 or older * Sexually active * Singleton, term (37 weeks 0 days) birth * Planning to breastfeed or pump during the study period * History of successful breastfeeding or pumping after a prior pregnancy * Between 6 weeks and 6 months postpartum (patients may be recruited at…
Contacts

Susan D Wherley, MD

216-844-1446

susan.wherley@uhhospitals.org

CONTACT

Rosemary Brewka

216-844-1446

rosemary.brewka@uhhospitals.org

CONTACT