The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury
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Eligibility Criteria
Inclusion Criteria:
* Age 18-70 years
* Spinal cord injury occurring at least 2 years prior to study entry
* Neurological level of injury (LOI) between C4 and L2
* American Spinal Injury Association Impairment Scale (AIS) A-D
* English-speaking.
Exclusion Criteria:
* Cognitive dysfunction that li…
Inclusion Criteria:
* Age 18-70 years
* Spinal cord injury occurring at least 2 years prior to study entry
* Neurological level of injury (LOI) between C4 and L2
* American Spinal Injury Association Impairment Scale (AIS) A-D
* English-speaking.
Exclusion Criteria:
* Cognitive dysfunction that limits ability to adequately understand the risks of the study or are otherwise unable to consent
* Health conditions associated with chronic systemic inflammation unrelated to weight or adiposity (e.g., systemic autoimmune diseases, recurrent or active urinary tract infection, pressure injury \> Stage 2)
* Conditions that preclude measurement of body composition by dual-energy x-ray absorptiometry (DXA; e.g., lower limb contracture \> 15 degrees)
* Inability to obtain free-flowing blood from a superficial forearm or hand vein
* Pregnant women
* Prisoners
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