Taiwan Associated Genetic and Nongenetic Small Vessel Disease
Recruiting
Observational Study
Cerebral Small Vessel Diseases
Cadasil
HTRA1-Related Autosomal Dominant Cerebral Angiopathy
COL4A1-Related Brain Small Vessel Disease With Haemorrhage
Fabry Disease
Magnetic Resonance Imaging
Next-generation Sequencing
Stroke
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 500 (estimated)
- Sponsor
- National Taiwan University Hospital · Other
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About This Trial
The TAG-SVD enrolled patients with clinical and neuroimaging features of cerebral small vessel disease (CSVD). All enrolled patients will receive next-generation sequence (NGS) with probes designed to target five candidate CSVD genes, and patients will be divided into genetic or non-genetic groups accordingly. Their clinical features and outcome will be followed for at least 2 years.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Participants must have at least one of the following symptoms/signs or history
* stroke (especially small vessel occlusion type of ischaemic stroke, spontaneous ICH or young stroke)
* cognitive impairment or dementia
* gait disturbance
* parkinsonism (especially vascular parkin…
Contacts